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As an example, consider the glucagon-like peptide-1 (GLP-1) and its analoguesagonists of GLP-1 receptor (GLP-1R), a system representing one of the cornerstones underlying the regulatory concept of integrative physiology which explains the coordinated functioning of the body

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The enzyme glutathione reductase can convert GSSG back to GSH using NADPH as a cofactor, which is an important part of cellular defenses against oxidative stress

The images compare the GLP-1 receptor (GLP-1R) structures obtained through cryo-electron microscopy (cryoEM) and AlphaFold 3 prediction